An older study from 2007 investigated factors that may predict reduced survival in CKD cats. The study involved a total of 190 cats with chronic kidney disease (= CKD) and was able to identify several prognostic factors. Although there are now other prognostic factors such as the blood concentration of Indoxyl sulfate or FGF-23, some of the prognostic factors from 2007 are still important in the...
Clinical symptoms of uraemia can include mouth ulcers, vomiting, loss of appetite and lethargy. These affect the quality of life of affected CKD cats. A number of treatment techniques to slow and prevent the development of uraemia are currently being investigated and should be considered in cats with CKD.
Recent studies suggest that the metabolic end-products of gut bacteria, which result from the breakdown of essential amino acids, may have a negative impact on cardiovascular health. As these diseases are the leading cause of death in humans, knowledge of these metabolites and the potential to influence their formation is a new approach to heart health.
Cats with CKD suffer not only from the consequences of diseased kidneys but also from the effects of the gut-kidney axis. This involves the gut microbiota, which is the totality of bacteria, viruses and protozoa that live in the gut. Uraemic toxins such as indoxyl sulphate frequently disturb the balance of these microbes, resulting in a dysbiosis, an imbalance of the microbes. It can also...
Cats with chronic kidney disease (CKD) develop azotaemia and, in later stages, uraemia. What exactly are these conditions and how do they differ?
Farewell Dear readers, For more than 5 years now, my website cat.life and the accompanying blog have been my own personal project. The focus has always been on the scientific aspects of the complexity of chronic kidney disease in cats. Driven by personal experiences with my own cat, I have always aimed to provide you with the information that many people are desperately looking for in a clear...
An american study now provides ambivalent insights into the use of kidney diets in combination with feed additives.
In chronic kidney disease in humans, uraemic toxins (U-Tox for short) play such an important role that a European research group is dedicated to this topic alone. This research group defines uraemic toxins as follows: blood and tissue levels of the toxin must be substantially elevated during chronic kidney disease (CKD). high concentrations of the toxin are directly related to one or more...
The kidneys play a central role in maintaining calcium and phosphate blood levels. Calcium and phosphate are in balance. In chronic kidney disease (CKD), this balance can be severely disturbed.
Amino acids are needed to make proteins. However, CKD cats have a disturbed serum amino acid profile. There is a lack of essentials