Increased acidity of the blood and the body. Metabolic acidosis occurs in chronic Loss of kidney function, which may be sudden (acute) or gradual (chronic), as in chronic kidney disease. Loss of kidney function leads to a reduced filtration capacity (glomerular filtration rate) and, thus, an inability to sufficiently filter out urinary substances such as uraemic toxins. Renal... due to A raised level in the blood of urea and other urinary substances, which in chronic kidney disease can no longer be adequately excreted due to impaired renal function (glomerular filtration rate). This leads to renal damage due to uraemic toxins, toxic urinary substances The symptoms... (raised blood Urea is the nitrogen-containing breakdown product of protein metabolism. The nitrogen from the proteins is converted to ammonia in the liver, which is combined with carbon dioxide to form urea. This is continuously excreted via the kidneys but also via sweat. Urea is one of...) but can also have many other metabolic causes.