A raised level in the blood of urea and other urinary substances, which in chronic kidney disease can no longer be adequately excreted due to impaired renal function (glomerular filtration rate). This leads to renal damage due to uraemic toxins, toxic urinary substances The symptoms of uraemia are itching, gastrointestinal problems, nausea, vomiting, bleeding due to inflammation of the gastric...

Toxic, nitrogen-containing urinary substances responsible for uraemia and kidney damage.

Urea is the nitrogen-containing breakdown product of protein metabolism. The nitrogen from the proteins is converted to ammonia in the liver, which is combined with carbon dioxide to form urea. This is continuously excreted via the kidneys but also via sweat. Urea is one of the urinary substances and is a measure of the amount of uraemic toxins in the blood, which also arise from protein...