Increased protein in urine, leading to loss of protein. Normally, only a very small amount of protein is excreted in the urine. In chronic kidney disease, the amount lost may increase. High blood pressure damages blood vessels in the Nephrone sind die Filtereinheiten der Nieren.... making them more permeable and causing more protein to pass into the urine. To compound this, the fact that the kidneys are damaged means they have less ability to reabsorb the proteins in the urine.