Secondary hyperparathyroidism

Hypocalcaemia (lowered blood calcium) in chronic kidney disease, as well as in liver or intestinal diseases, can lead to uncontrolled production of parathyroid hormone (PTH) in the parathyroid gland. As a result, the parathyroid glands, react less and less to calcium as a stop signal (down-regulation of calcium receptors), increasing production of PTH. Increased PTH in the blood results in continuous bone resorption and eventually softening of the bones. Furthermore, the calcium released into the blood can lead to kidney stones and seriously affect the health of kidneys, heart, blood vessels and skin.