Uraemic Toxins

Toxic, nitrogen-containing urinary substances responsible for uraemia and kidney damage. The concentration of these substances can increase in the blood if the filtration ability of the kidneys (glomerular filtration rate) is reduced. The uraemic toxins can then directly damage the kidneys and lead to the symptoms associated with uraemia. The best-studied uraemic toxins include indoxyl sulphate, which contributes directly to the progression of renal failure in CKD and can impede blood formation, and para-cresyl sulphate.