A raised level in the blood of urea and other urinary substances, which in chronic kidney disease can no longer be adequately excreted due to impaired renal function (glomerular filtration rate). This leads to renal damage due to uraemic toxins, toxic urinary substances The symptoms of uraemia are itching, gastrointestinal problems, nausea, vomiting, bleeding due to inflammation of the gastric mucosa (gastritis), intestinal inflammation, pericarditis, water in the lungs (pulmonary oedema) accompanied by shortness of breath, neurological disorders (from tremors to coma), impairment of blood production (potentiallyanaemia), and bad breath. Can also cause changes in muscles, stiffness, abnormal movements, aversion to movement, aversion to eating, fatigue, lethargy and weakness.